EFFECTIVENESS OF Moringa (Moringa oleifera) LEAVES ETHANOL EXTRACT ON REDUCING CHOLESTEROL LEVELS IN MALE WHITE RATS (Rattus norvegicus) INDUCED WITH QUAIL EGG YOLKS

Abstract

Cholesterol is a fatty substance contained in the body. Excessive cholesterol will accumulate in the walls of blood vessels, which can cause atherosclerosis (narrowing of the blood vessels) as a driving factor for coronary heart disease. The aim of this research was to determine the effectiveness of administering Moringa leaf extract on reducing cholesterol from Moringa oleifera leaf extract in male white rats Rattus norvegicus and to determine the concentration of Moringa leaf extract on the effect of reducing cholesterol in male white rats (Rattus norvegicus). This research is an experimental study which consists of several stages including: extract characterization and testing the effect of reducing cholesterol. The data obtained was analyzed by ANOVA (analysis of variance) and continued with the post hoc test. The samples in this study were male white rats, Rattus norvegicus, aged 8-12 weeks, weighing 200-300 gr. The research sample consisted of 30 male Rattus norvegicus rats. The results of the analysis found that the mean cholesterol of the rats before treatment was highest in the positive group (Simvastatin) of 155.8 mg/dl while the lowest was in the group of doses of 150 mh/kg BB, which was 132.2 mg/dl. The average cholesterol of rats after treatment, the highest was in the negative control group (CMC-Na) of 217.8 mg/dl while the lowest was at a dose level of 450 mg/kg BW which was 116.8 mg/dl.